Going Beyond Integrative Care to "Functional Medicine"
Pervasive in modern society, stress permeates the human experience. Its complexity mirrors that of the human make-up and of the world around us, explained Ronald P. Ciccone, MD, director of Lourdes Integrative Family Medicine at the fifth annual Explorations in Integrative Medicine symposium, presented by the Lourdes Wellness Center and Lourdes Health System in March 2009.
"Stress is everywhere. We can't get away from it," said Dr. Ciccone. And, its solutions
are
In his keynote address, "The Full Spectrum of Stress", Dr. Ciccone outlined the myriad effects of stress and the range of alternative therapies available for it. He laid out the challenge for clinicians in caring for stress-related conditions: To conduct functional medicine—a brand of integrative medicine that focuses on addressing causes rather than symptoms and that looks at family history, nutrition, metabolism and other interconnected systems simultaneously.
Inclusiveness Essential
Using stress as an example of the breadth of interplay of factors and therapies that affect health, Dr. Ciccone suggested, "We should be cautious about the term 'alternative medicine' because it suggests two opposing camps of medicine, when in fact alternative and mainstream medicine are highly overlapping and synergistic."
Integrative medicine seeks to combine the
best ideas and practices of mainstream and
alternative medicine into effective treatments
that will be in the best interests of patients
and that aim to stimulate the body's own
natural healing potentials. It neither rejects
mainstream medicine nor embraces
alternative practices uncritically. It strives for
optimal health and prevention ~V and
considers a person's biochemical individuality.
—Ronald P. Ciccone, MD
The Set Up: Genes + Exposures
Dr. Ciccone noted that just as one disease can have many causes, so one cause can precipitate many diseases. Stress is a primary example of a factor with disseminated effects, but one that, conversely, can have its own physical basis as well."Just reaching for a magic-bullet treatment for the end-manifestation of stress is like putting a Band-Aid on a much bigger problem," he explained, citing the importance of the recent book by Mark Hyman (see sidebar), which looks at the effect of basic biology and wellness on the mind.
Dr. Ciccone referenced the importance of two areas:
- Genes and the environment: Particularly, nutrition has a cell-signaling
affect influencing the expression of genes. Thus, the importance of what is and isn't
in food. Traces of pesticide have a neurotoxic impact, even as traces of essential,
naturally occurring minerals may be absent. The blood-brain and gastrointestinal
barriers to unhealthy nutrition are weaker in some individuals. In discussing
biomarkers for stress and mood susceptibility, Dr. Ciccone cited the work of Coriell
Institute (see sidebar) in Camden.
- Neurotransmitters: Exposures and diet also influence cytokines, which are "conductors of the orchestra of transmitters and hormones in the body." Dr.Ciccone pointed out that, "Neurons don't connect, they signal." Not only can drugs deplete the neurochemicals needed for signaling, but stress and medications can overburden production and release of these transmitters. With the duress that constant, short-term stress places on the adrenal gland, the body can also go into cortisol deficiency or can develop conditions such as hypertension. Dr. Ciccone mentioned the utility of Ansar testing and the RESPeRATE device (see sidebar) for addressing such phenomena.
The Accidental Psychiatrist

To care for stress-related conditions, clinicians must address the causes rather than symptoms, focusing on family, medical and personal history, as well as nutrition and other interconnected systems, according to Ronald Ciccone, MD.
Reviewing the complexity of healing, Dr. Ciccone discussed quantum analysis and fractals, referencing these unifying, particle- and sub-particle level frameworks as a way to understand the fundamental systems that are the basis for health and disease. "With an appreciation of these constructs, we see that wellness goes far beyond linear, Newtownian, cause-effect physics and takes into account the energy from the total environment around us," he explained, citing acupuncture as an example of a therapy that intervenes along the body's meridians of energy.
"A working sense of the intricate nature of wellness helps us explain, for instance, the potency of placebos, an effect in which something is working therapeutically but we just don't always understand what," he elaborated. "For example, we didn't understand why running gave a sense of well-being until we discovered brain endorphins."
Maintaining that healthcare knowledge often runs well ahead of healthcare practice, he noted the significant obligation on the part of clinicians to use and discuss integrative interventions that have a good safety record, especially in addressing stress or stress-related conditions.
To learn more about Lourdes Integrative Family Medicine, call 856-869-3126.

